Photo of Professor Manjit Matharu

Professor Manjit Matharu

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GMC/GDC number:

4090760

Professional background

Professor Manjit Matharu is a professor of neurology at UCL Queen Square Institute of Neurology, visiting professor of neurology at the Department of Neuromedicine and Movement sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway and honorary consultant neurologist at The National Hospital for Neurology and Neurosurgery.

He is the clinical and academic lead of the Headache and Facial Pain Group at The National Hospital for Neurology and Neurosurgery and UCL Queen Square Institute of Neurology, respectively. Dr Matharu gained his BSc and MBChB from the University of Manchester in 1991 and 1994, respectively. He completed his general medical training in London leading up to obtaining the membership of the Royal College of Physicians (MRCP) in 1998. He subsequently obtained a PhD at The Institute of Neurology, Queen Square, London on structural and functional neuroimaging in primary headache syndromes. He completed his residency in neurology at The National Hospital for Neurology and Neurosurgery, The Royal London Hospital and Homerton Hospital in London in 2007.

His major research interests include migraine, trigeminal autonomic cephalalgias, facial pain, neurostimulation for intractable headaches, spontaneous intracranial hypotension and other headache disorders in hypermobility syndromes.

He has authored numerous scientific papers. Professor Matharu is a core team member of the International Headache Society (IHS) Regional Outreach Programme, President of the Medical Advisory Board of the CSF Leak Association and Chairperson of the UK CSF Leak Special Interest group. He was a member of the NICE guideline development committee for the headache guidelines.

Research interests

  • Headaches
  • Facial pain
  • Trigeminal neuralgia
  • CSF leaks (Spontaneous intracranial hypotension)

Publications

  • Cheema S, Mehta D, Ray JC, Hutton EJ, Matharu MS. New daily persistent headache: A systematic review and meta-analysis. Cephalalgia. 2023;43(5)
  • Cheema S, Stubberud A, Rantell K, Nachev P, Tronvik E, Matharu M. Phenotype of new daily persistent headache: subtypes and comparison to transformed chronic daily headache. J Headache Pain. 2023;24(1):109.
  • Musubire AK, Cheema S, Ray JC, Hutton EJ, Matharu M. Cytokines in primary headache disorders: a systematic review and meta-analysis. The Journal of Headache and Pain. 2023;24(1):36.
  • Simmonds L, Lagrata S, Stubberud A, Cheema S, Tronvik E, Matharu M, Kamourieh S. An open-label observational study and meta-analysis of non-invasive vagus nerve stimulation in medically refractory chronic cluster headache. Frontiers in neurology. 2023;14
  • Stubberud A, Ingvaldsen SH, Brenner E, Winnberg I, Olsen A, Gravdahl GB, Matharu MS, Nachev P, Tronvik E. Forecasting migraine with machine learning based on mobile phone diary and wearable data. Cephalalgia. 2023;43(5)
  • Cheema S, Anderson J, Angus-Leppan H, Armstrong P, Butteriss D, Carlton Jones L, Choi D, Chotai A, D'Antona L, Davagnanam I, Davies B, Dorman PJ, Duncan C, Ellis S, Iodice V, Joy C, Lagrata S, Mead S, Morland D, Nissen J, Pople J, Redfern N, Sayal PP, Scoffings D, Secker R, Toma AK, Trevarthen T, Walkden J, Beck J, Kranz PG, Schievink W, Wang SJ, Matharu MS. Multidisciplinary consensus guideline for the diagnosis and management of spontaneous intracranial hypotension. J Neurol Neurosurg Psychiatry. 2023.
  • Underwood M, Achana F, Carnes D, Eldridge S, Ellard D, Griffiths F, Haywood K, Hee SW, Higgins H, Mistry D, Mistry H, Newton S, Nichols V, Norman C, Padfield E, Patel S, Petrou S, Pincus T, Potter R, Sandhu H, Stewart K, Taylor SJ, Matharu MS. A Supportive Self-Management Program for People with Chronic Headaches and Migraine: A Randomized Controlled Trial and Economic Evaluation. Neurology. 2022.
  • O'Connor E, Nikram E, Grangeon L, Danno D, Houlden H, Matharu M. The clinical characteristics of familial cluster headache. Cephalalgia. 2022;42(8):715-21
  • Schoenen J, Snoer AH, Brandt RB, Fronczek R, Wei DY, Chung CS, Diener HC, Dodick DW, Fontaine D, Goadsby PJ, Matharu MS, May A, McGinley JS, Tepper SJ, Jensen RH, Ferrari MD, Trials IHSSCfC, subcommittee IHSchtg. Guidelines of the International Headache Society for Controlled Clinical Trials in Cluster Headache. Cephalalgia. 2022;42(14):1450-66.
  • Stubberud A, Gray R, Tronvik E, Matharu M, Nachev P. Machine prescription for chronic migraine. Brain Commun. 2022;4(3)
  • Lambru G, Lagrata S, Levy A, Cheema S, Davagnanam I, Rantell K, et al. Trigeminal microvascular decompression for short-lasting unilateral neuralgiform headache attacks. Brain. 2022;145(8):2882-93.
  • O'Connor E, Fourier C, Ran C, Sivakumar P, Liesecke F, Southgate L, et al. Genome-Wide Association Study Identifies Risk Loci for Cluster Headache. Ann Neurol. 2021;90(2):193-202.
  • Tso AR, Brudfors M, Danno D, Grangeon L, Cheema S, Matharu M, et al. Machine phenotyping of cluster headache and its response to verapamil. Brain. 2021;144(2):655-64.
  • D'Antona L, Jaime Merchan MA, Vassiliou A, Watkins LD, Davagnanam I, Toma AK, et al. Clinical Presentation, Investigation Findings, and Treatment Outcomes of Spontaneous Intracranial Hypotension Syndrome: A Systematic Review and Meta-analysis. JAMA Neurol. 2021;78(3):329-37.
  • D'Antona L, Asif H, Craven CL, McHugh JA, Vassiliou A, Thorne L, et al. Brain MRI and Ophthalmic Biomarkers of Intracranial Pressure. Neurology. 2021.
  • Lambru G, Rantell K, O'Connor E, Levy A, Davagnanam I, Zrinzo L, et al. Trigeminal neurovascular contact in SUNCT and SUNA: a cross-sectional magnetic resonance study. Brain. 2020;143(12):3619-28.
  • Lambru G, Rantell K, Levy A, Matharu MS. A prospective comparative study and analysis of predictors of SUNA and SUNCT. Neurology. 2019;93(12):e1127-e37.
  • D'Antona L, McHugh JA, Ricciardi F, Thorne LW, Matharu MS, Watkins LD, et al. Association of Intracranial Pressure and Spontaneous Retinal Venous Pulsation. JAMA Neurol. 2019.
  • Skljarevski V, Matharu M, Millen BA, Ossipov MH, Kim BK, Yang JY. Efficacy and safety of galcanezumab for the prevention of episodic migraine: Results of the EVOLVE-2 Phase 3 randomized controlled clinical trial. Cephalalgia. 2018;38(8):1442-54.
  • Matharu M, Halker R, Pozo-Rosich P, DeGryse R, Manack Adams A, Aurora SK. The impact of onabotulinumtoxinA on severe headache days: PREEMPT 56-week pooled analysis. J Headache Pain. 2017;18(1):78.
  • Matharu M, Pascual J, Nilsson Remahl I, Straube A, Lum A, Davar G, et al. Utilization and safety of onabotulinumtoxinA for the prophylactic treatment of chronic migraine from an observational study in Europe. Cephalalgia. 2017;37(14):1384-97.
  • Akram H, Miller S, Lagrata S, Hariz M, Ashburner J, Behrens T, et al. Optimal deep brain stimulation site and target connectivity for chronic cluster headache. Neurology. 2017;89(20):2083-91.
  • Miller S, Watkins L, Matharu MS. Treatment of intractable hemicrania continua by occipital nerve stimulation. J Neurol Neurosurg Psychiatry. 2017;88(9):805-6.
  • Miller S, Akram H, Lagrata S, Hariz M, Zrinzo L, Matharu M. Ventral tegmental area deep brain stimulation in refractory short-lasting unilateral neuralgiform headache attacks. Brain. 2016;139(Pt 10):2631-40.
  • Akram H, Miller S, Lagrata S, Hyam J, Jahanshahi M, Hariz M, et al. Ventral tegmental area deep brain stimulation for refractory chronic cluster headache. Neurology. 2016;86(18):1676-82.
  • Cittadini E, Matharu MS, Goadsby PJ. Paroxysmal hemicrania: a prospective clinical study of 31 cases. Brain 2008;131(Pt 4):1142-1155.
  • Cohen AS, Matharu MS, Goadsby PJ. Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA)-a prospective clinical study of SUNCT and SUNA. Brain 2006; 129: 2746-60.
  • Schwedt TJ, Matharu MS, Dodick DW. Thunderclap headache. Lancet Neurol 2006; 5: 621-31.
  • Matharu MS, Cohen AS, Frackowiak RS, Goadsby PJ. Posterior hypothalamic activation in paroxysmal hemicrania. Ann Neurol 2006; 59: 535-545.
  • Levy MJ, Matharu MS, Meeran K, Powell M, Goadsby PJ. The clinical characteristics of headache in patients with pituitary tumours. Brain 2005; 128: 1921-30.
  • Afridi SK, Matharu MS, Lee L, Kaube H, Friston KJ, Frackowiak RS, et al. A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain 2005;128:932-939.
  • Matharu MS, Levy MJ, Meeran K, Goadsby PJ. Subcutaneous octreotide in cluster headache: Randomized placebo-controlled double-blind crossover study. Ann Neurol 2004; 56:488-494.
  • Matharu MS, Bartsch T, Ward N, Frackowiak RS, Weiner R, Goadsby PJ. Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain 2004; 127:220-230.

 

: Kernick D and Goadsby P, editors. Headache: A Practical Manual. New York: Oxford University Press, 2008: 143-166.